RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve drug addiction including selectively decrease cocaine self-administration.

Product information

CAS Number: 847554-50-1

Molecular Weight: 448.56

Formula: C26H32N4O3

Chemical Name: 3-oxo-1,1-diphenyl-N-[2-(piperidin-1-yl)ethyl]-hexahydro-1H-[1,3]oxazolo[3,4-a]pyrazine-7-carboxamide

Smiles: O=C1OC(C2CN(CCN12)C(=O)NCCN1CCCCC1)(C1C=CC=CC=1)C1C=CC=CC=1

InChiKey: JJDDRYMIPIEXKX-UHFFFAOYSA-N

InChi: InChI=1S/C26H32N4O3/c31-24(27-14-17-28-15-8-3-9-16-28)29-18-19-30-23(20-29)26(33-25(30)32,21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-2,4-7,10-13,23H,3,8-9,14-20H2,(H,27,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RTI-118 (109 nM) has a reduction in antagonist potency at the NPS 107I variant.

In Vivo:

RTI-118 (5-30 mg/kg, intraperitoneal injection; pre-30 minutes) is well tolerated in rats with no significant outward signs of aversion, sedation or toxicity, it also produces a dose-related decrease in cocaine and food self-administration; however these effects are selective for cocaine at lower doses (10 and 20 mg/kg).

Products are for research use only. Not for human use.