Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.

Product information

CAS Number: 123039-93-0

Molecular Weight: 267.32

Formula: C17H17NO2

Chemical Name: (6aR,12bS)-5H,6H,6aH,7H,8H,12bH-benzo[a]phenanthridine-10,11-diol

Smiles: OC1C=C2CC[C@H]3NCC4C=CC=CC=4[C@@H]3C2=CC=1O

InChiKey: BGOQGUHWXBGXJW-RHSMWYFYSA-N

InChi: InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells.

In Vivo:

Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h. Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo.

Products are for research use only. Not for human use.