Phospho-LRRK2 (Ser395) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16573-50, BZ16573-100

Product: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Swiss-Prot: Q5S007

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB,ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Filamin A Phosphorylation in WTLRRK2Lysates treated LRRK2 using Phospho-LRRK2 antibody.

Bioworld Molecular Weight: Calculated MW: 286 kDa; Observed MW: 286 kDa

Specificity: IgG

Alternative Name: AURA17; Dardarin antibody; ; Leucine rich repeat kinase 2; LRRK 2 antibody; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2

Immunogen: A synthesized peptide derived from human Phospho-LRRK2 (S935)

Conjugate: Unconjugated

Modification: Phosphorylated