Dotinurad is a potent and selective urate reabsorption inhibitor. Dotinurad inhibits urate transporter 1 (URAT1) with an IC50 value of 37.2 nM. Dotinurad acts as a uricosuric agent.

Product information

CAS Number: 1285572-51-1

Molecular Weight: 358.20

Formula: C14H9Cl2NO4S

Chemical Name: 3-(3,5-dichloro-4-hydroxybenzoyl)-2,3-dihydro-1λ⁶,3-benzothiazole-1,1-dione

Smiles: OC1C(Cl)=CC(=CC=1Cl)C(=O)N1CS(=O)(=O)C2=CC=CC=C12

InChiKey: VOFLAIHEELWYGO-UHFFFAOYSA-N

InChi: InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 65 mg/mL (181.46 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dotinurad has higher selectivity for urate transporter 1 (URAT1) versus ATP-binding cassette subfamily G member 2 (ABCG2) and organic anion transporter (OAT) 1/3. Dotinurad weakly inhibits ABCG2, OAT1, and OAT3, with IC50 values of 4.16, 4.08, and 1.32 μM, respectively.

In Vivo:

Dotinurad exhibits low oral bioavailability (2.5 %) and Cmax (415 ng/mL) following oral administration (1.3 mg/kg). Dotinurad also exhibits terminal elimination half-life (T1/2 1.88 h) due to high plasma clearance (24126 mL/h/kg) following oral administration (1.3 mg/kg) in Sprague-Dawley rats.

Products are for research use only. Not for human use.