KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent.

Product information

CAS Number: 129200-10-8

Molecular Weight: 546.57

Formula: C27H34N2O10

Chemical Name: (2E)-but-2-enedioic acid; 4-methoxyphenyl 2-{4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl}acetate

Smiles: COC1C=CC(=CC=1)OC(=O)CN1CCN(CC2C=C(OC)C(OC)=C(C=2)OC)CC1.OC(=O)/C=C/C(O)=O

InChiKey: JUOYRBCKLAPYBI-WLHGVMLRSA-N

InChi: InChI=1S/C23H30N2O6.C4H4O4/c1-27-18-5-7-19(8-6-18)31-22(26)16-25-11-9-24(10-12-25)15-17-13-20(28-2)23(30-4)21(14-17)29-3;5-3(6)1-2-4(7)8/h5-8,13-14H,9-12,15-16H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (457.40 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

KB-5492 (0.001-100 μM) inhibits specific [3H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.

In Vivo:

KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa.

Products are for research use only. Not for human use.